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\frac{4}{3}-\frac{2\times 81}{9}-\frac{16}{243}
Express \frac{2}{9}\times 81 as a single fraction.
\frac{4}{3}-\frac{162}{9}-\frac{16}{243}
Multiply 2 and 81 to get 162.
\frac{4}{3}-18-\frac{16}{243}
Divide 162 by 9 to get 18.
\frac{4}{3}-\frac{54}{3}-\frac{16}{243}
Convert 18 to fraction \frac{54}{3}.
\frac{4-54}{3}-\frac{16}{243}
Since \frac{4}{3} and \frac{54}{3} have the same denominator, subtract them by subtracting their numerators.
-\frac{50}{3}-\frac{16}{243}
Subtract 54 from 4 to get -50.
-\frac{4050}{243}-\frac{16}{243}
Least common multiple of 3 and 243 is 243. Convert -\frac{50}{3} and \frac{16}{243} to fractions with denominator 243.
\frac{-4050-16}{243}
Since -\frac{4050}{243} and \frac{16}{243} have the same denominator, subtract them by subtracting their numerators.
-\frac{4066}{243}
Subtract 16 from -4050 to get -4066.