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Differentiate w.r.t. x
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\frac{2x}{\left(x-4y\right)\left(x+4y\right)}-\frac{1}{x-4y}
Factor x^{2}-16y^{2}.
\frac{2x}{\left(x-4y\right)\left(x+4y\right)}-\frac{x+4y}{\left(x-4y\right)\left(x+4y\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of \left(x-4y\right)\left(x+4y\right) and x-4y is \left(x-4y\right)\left(x+4y\right). Multiply \frac{1}{x-4y} times \frac{x+4y}{x+4y}.
\frac{2x-\left(x+4y\right)}{\left(x-4y\right)\left(x+4y\right)}
Since \frac{2x}{\left(x-4y\right)\left(x+4y\right)} and \frac{x+4y}{\left(x-4y\right)\left(x+4y\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{2x-x-4y}{\left(x-4y\right)\left(x+4y\right)}
Do the multiplications in 2x-\left(x+4y\right).
\frac{x-4y}{\left(x-4y\right)\left(x+4y\right)}
Combine like terms in 2x-x-4y.
\frac{1}{x+4y}
Cancel out x-4y in both numerator and denominator.