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\frac{24x\left(x^{3}+1\right)^{\frac{3}{2}}-3x^{4}\times 72\left(x^{3}+1\right)^{\frac{1}{2}}}{16\left(x^{3}+1\right)^{\frac{3}{2}}}
To multiply powers of the same base, add their exponents. Add 2 and 2 to get 4.
\frac{24x\left(x^{3}+1\right)^{\frac{3}{2}}-216x^{4}\left(x^{3}+1\right)^{\frac{1}{2}}}{16\left(x^{3}+1\right)^{\frac{3}{2}}}
Multiply 3 and 72 to get 216.
\frac{24x\left(2x-1\right)\sqrt{x^{3}+1}\left(-4x^{2}-2x-1\right)}{16\left(x^{3}+1\right)^{\frac{3}{2}}}
Factor the expressions that are not already factored.
\frac{3x\left(2x-1\right)\left(-4x^{2}-2x-1\right)}{2\left(x^{3}+1\right)}
Cancel out 8\sqrt{x^{3}+1} in both numerator and denominator.
\frac{-24x^{4}+3x}{2x^{3}+2}
Expand the expression.