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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{2}{1}x^{\frac{1}{2}-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(2x^{-\frac{3}{2}})
Do the arithmetic.
-\frac{3}{2}\times 2x^{-\frac{3}{2}-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-3x^{-\frac{5}{2}}
Do the arithmetic.