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\frac{16!}{8!\times \left(2!\right)^{2}\times 2!}
Multiply 2! and 2! to get \left(2!\right)^{2}.
\frac{16!}{8!\times \left(2!\right)^{3}}
To multiply powers of the same base, add their exponents. Add 2 and 1 to get 3.
\frac{20922789888000}{8!\times \left(2!\right)^{3}}
The factorial of 16 is 20922789888000.
\frac{20922789888000}{40320\times \left(2!\right)^{3}}
The factorial of 8 is 40320.
\frac{20922789888000}{40320\times 2^{3}}
The factorial of 2 is 2.
\frac{20922789888000}{40320\times 8}
Calculate 2 to the power of 3 and get 8.
\frac{20922789888000}{322560}
Multiply 40320 and 8 to get 322560.
64864800
Divide 20922789888000 by 322560 to get 64864800.