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\frac{20922789888000}{\left(16-5\right)!\times 5!}
The factorial of 16 is 20922789888000.
\frac{20922789888000}{11!\times 5!}
Subtract 5 from 16 to get 11.
\frac{20922789888000}{39916800\times 5!}
The factorial of 11 is 39916800.
\frac{20922789888000}{39916800\times 120}
The factorial of 5 is 120.
\frac{20922789888000}{4790016000}
Multiply 39916800 and 120 to get 4790016000.
4368
Divide 20922789888000 by 4790016000 to get 4368.