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Differentiate w.r.t. x
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\frac{\left(5x^{1}-4\right)\frac{\mathrm{d}}{\mathrm{d}x}(10x^{2})-10x^{2}\frac{\mathrm{d}}{\mathrm{d}x}(5x^{1}-4)}{\left(5x^{1}-4\right)^{2}}
For any two differentiable functions, the derivative of the quotient of two functions is the denominator times the derivative of the numerator minus the numerator times the derivative of the denominator, all divided by the denominator squared.
\frac{\left(5x^{1}-4\right)\times 2\times 10x^{2-1}-10x^{2}\times 5x^{1-1}}{\left(5x^{1}-4\right)^{2}}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{\left(5x^{1}-4\right)\times 20x^{1}-10x^{2}\times 5x^{0}}{\left(5x^{1}-4\right)^{2}}
Do the arithmetic.
\frac{5x^{1}\times 20x^{1}-4\times 20x^{1}-10x^{2}\times 5x^{0}}{\left(5x^{1}-4\right)^{2}}
Expand using distributive property.
\frac{5\times 20x^{1+1}-4\times 20x^{1}-10\times 5x^{2}}{\left(5x^{1}-4\right)^{2}}
To multiply powers of the same base, add their exponents.
\frac{100x^{2}-80x^{1}-50x^{2}}{\left(5x^{1}-4\right)^{2}}
Do the arithmetic.
\frac{\left(100-50\right)x^{2}-80x^{1}}{\left(5x^{1}-4\right)^{2}}
Combine like terms.
\frac{50x^{2}-80x^{1}}{\left(5x^{1}-4\right)^{2}}
Subtract 50 from 100.
\frac{10x\left(5x^{1}-8x^{0}\right)}{\left(5x^{1}-4\right)^{2}}
Factor out 10x.
\frac{10x\left(5x-8x^{0}\right)}{\left(5x-4\right)^{2}}
For any term t, t^{1}=t.
\frac{10x\left(5x-8\right)}{\left(5x-4\right)^{2}}
For any term t except 0, t^{0}=1.