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Differentiate w.r.t. x
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\frac{x^{4}-x+1}{\left(x^{4}+x+1\right)\left(x^{4}-x+1\right)}-\frac{x^{4}+x+1}{\left(x^{4}+x+1\right)\left(x^{4}-x+1\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x^{4}+x+1 and x^{4}-x+1 is \left(x^{4}+x+1\right)\left(x^{4}-x+1\right). Multiply \frac{1}{x^{4}+x+1} times \frac{x^{4}-x+1}{x^{4}-x+1}. Multiply \frac{1}{x^{4}-x+1} times \frac{x^{4}+x+1}{x^{4}+x+1}.
\frac{x^{4}-x+1-\left(x^{4}+x+1\right)}{\left(x^{4}+x+1\right)\left(x^{4}-x+1\right)}
Since \frac{x^{4}-x+1}{\left(x^{4}+x+1\right)\left(x^{4}-x+1\right)} and \frac{x^{4}+x+1}{\left(x^{4}+x+1\right)\left(x^{4}-x+1\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{x^{4}-x+1-x^{4}-x-1}{\left(x^{4}+x+1\right)\left(x^{4}-x+1\right)}
Do the multiplications in x^{4}-x+1-\left(x^{4}+x+1\right).
\frac{-2x}{\left(x^{4}+x+1\right)\left(x^{4}-x+1\right)}
Combine like terms in x^{4}-x+1-x^{4}-x-1.
\frac{-2x}{x^{8}+2x^{4}-x^{2}+1}
Expand \left(x^{4}+x+1\right)\left(x^{4}-x+1\right).