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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{32zy^{2}}{4z}\right)x^{2-1})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-8y^{2}\right)x^{1})
Do the arithmetic.
\left(-8y^{2}\right)x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-8y^{2}\right)x^{0}
Do the arithmetic.
\left(-8y^{2}\right)\times 1
For any term t except 0, t^{0}=1.
-8y^{2}
For any term t, t\times 1=t and 1t=t.
-8xy^{2}
Cancel out 4xz in both numerator and denominator.