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Differentiate w.r.t. x
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\left(-32x^{12}\right)^{1}\times \frac{1}{4x^{8}}
Use the rules of exponents to simplify the expression.
\left(-32\right)^{1}\left(x^{12}\right)^{1}\times \frac{1}{4}\times \frac{1}{x^{8}}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
\left(-32\right)^{1}\times \frac{1}{4}\left(x^{12}\right)^{1}\times \frac{1}{x^{8}}
Use the Commutative Property of Multiplication.
\left(-32\right)^{1}\times \frac{1}{4}x^{12}x^{8\left(-1\right)}
To raise a power to another power, multiply the exponents.
\left(-32\right)^{1}\times \frac{1}{4}x^{12}x^{-8}
Multiply 8 times -1.
\left(-32\right)^{1}\times \frac{1}{4}x^{12-8}
To multiply powers of the same base, add their exponents.
\left(-32\right)^{1}\times \frac{1}{4}x^{4}
Add the exponents 12 and -8.
-32\times \frac{1}{4}x^{4}
Raise -32 to the power 1.
-8x^{4}
Multiply -32 times \frac{1}{4}.
\frac{\left(-32\right)^{1}x^{12}}{4^{1}x^{8}}
Use the rules of exponents to simplify the expression.
\frac{\left(-32\right)^{1}x^{12-8}}{4^{1}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\left(-32\right)^{1}x^{4}}{4^{1}}
Subtract 8 from 12.
-8x^{4}
Divide -32 by 4.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{32}{4}\right)x^{12-8})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(-8x^{4})
Do the arithmetic.
4\left(-8\right)x^{4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-32x^{3}
Do the arithmetic.