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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{12zy^{3}}{3y^{1}}\right)x^{3-4})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-4zy^{2}\right)\times \frac{1}{x})
Do the arithmetic.
-\left(-4zy^{2}\right)x^{-1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
4zy^{2}x^{-2}
Do the arithmetic.
\frac{-4zy^{2}}{x}
Cancel out 3yx^{3} in both numerator and denominator.