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Differentiate w.r.t. x
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\frac{x^{6}}{n^{4}}-\frac{256n^{4}}{n^{4}}
To add or subtract expressions, expand them to make their denominators the same. Multiply 256 times \frac{n^{4}}{n^{4}}.
\frac{x^{6}-256n^{4}}{n^{4}}
Since \frac{x^{6}}{n^{4}} and \frac{256n^{4}}{n^{4}} have the same denominator, subtract them by subtracting their numerators.