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\frac{4^{-1}\times 5^{-3}}{4^{5}\times 5^{6}}
To multiply powers of the same base, add their exponents. Add 2 and -3 to get -1.
\frac{1}{4^{6}\times 5^{9}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{1}{4096\times 5^{9}}
Calculate 4 to the power of 6 and get 4096.
\frac{1}{4096\times 1953125}
Calculate 5 to the power of 9 and get 1953125.
\frac{1}{8000000000}
Multiply 4096 and 1953125 to get 8000000000.