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\frac{81\times 2^{-2}\times 5^{-3^{1}}}{\left(-6\right)^{3}}
Calculate 3 to the power of 4 and get 81.
\frac{81\times \frac{1}{4}\times 5^{-3^{1}}}{\left(-6\right)^{3}}
Calculate 2 to the power of -2 and get \frac{1}{4}.
\frac{\frac{81}{4}\times 5^{-3^{1}}}{\left(-6\right)^{3}}
Multiply 81 and \frac{1}{4} to get \frac{81}{4}.
\frac{\frac{81}{4}\times 5^{-3}}{\left(-6\right)^{3}}
Calculate 3 to the power of 1 and get 3.
\frac{\frac{81}{4}\times \frac{1}{125}}{\left(-6\right)^{3}}
Calculate 5 to the power of -3 and get \frac{1}{125}.
\frac{\frac{81}{500}}{\left(-6\right)^{3}}
Multiply \frac{81}{4} and \frac{1}{125} to get \frac{81}{500}.
\frac{\frac{81}{500}}{-216}
Calculate -6 to the power of 3 and get -216.
\frac{81}{500\left(-216\right)}
Express \frac{\frac{81}{500}}{-216} as a single fraction.
\frac{81}{-108000}
Multiply 500 and -216 to get -108000.
-\frac{3}{4000}
Reduce the fraction \frac{81}{-108000} to lowest terms by extracting and canceling out 27.