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\frac{\frac{1}{4}+2\times 2}{\frac{5-\frac{5}{4}}{-\frac{4}{3}}}\left(\frac{4}{10}-4\right)^{-2}
Divide 2 by \frac{1}{2} by multiplying 2 by the reciprocal of \frac{1}{2}.
\frac{\frac{1}{4}+4}{\frac{5-\frac{5}{4}}{-\frac{4}{3}}}\left(\frac{4}{10}-4\right)^{-2}
Multiply 2 and 2 to get 4.
\frac{\frac{17}{4}}{\frac{5-\frac{5}{4}}{-\frac{4}{3}}}\left(\frac{4}{10}-4\right)^{-2}
Add \frac{1}{4} and 4 to get \frac{17}{4}.
\frac{\frac{17}{4}}{\frac{\frac{15}{4}}{-\frac{4}{3}}}\left(\frac{4}{10}-4\right)^{-2}
Subtract \frac{5}{4} from 5 to get \frac{15}{4}.
\frac{\frac{17}{4}}{\frac{15}{4}\left(-\frac{3}{4}\right)}\left(\frac{4}{10}-4\right)^{-2}
Divide \frac{15}{4} by -\frac{4}{3} by multiplying \frac{15}{4} by the reciprocal of -\frac{4}{3}.
\frac{\frac{17}{4}}{-\frac{45}{16}}\left(\frac{4}{10}-4\right)^{-2}
Multiply \frac{15}{4} and -\frac{3}{4} to get -\frac{45}{16}.
\frac{17}{4}\left(-\frac{16}{45}\right)\left(\frac{4}{10}-4\right)^{-2}
Divide \frac{17}{4} by -\frac{45}{16} by multiplying \frac{17}{4} by the reciprocal of -\frac{45}{16}.
-\frac{68}{45}\left(\frac{4}{10}-4\right)^{-2}
Multiply \frac{17}{4} and -\frac{16}{45} to get -\frac{68}{45}.
-\frac{68}{45}\left(\frac{2}{5}-4\right)^{-2}
Reduce the fraction \frac{4}{10} to lowest terms by extracting and canceling out 2.
-\frac{68}{45}\left(-\frac{18}{5}\right)^{-2}
Subtract 4 from \frac{2}{5} to get -\frac{18}{5}.
-\frac{68}{45}\times \frac{25}{324}
Calculate -\frac{18}{5} to the power of -2 and get \frac{25}{324}.
-\frac{85}{729}
Multiply -\frac{68}{45} and \frac{25}{324} to get -\frac{85}{729}.