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Differentiate w.r.t. x
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\frac{y\left(x-4\right)}{\left(x-4\right)\left(x+4\right)}-\frac{x\left(x+4\right)}{\left(x-4\right)\left(x+4\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x+4 and x-4 is \left(x-4\right)\left(x+4\right). Multiply \frac{y}{x+4} times \frac{x-4}{x-4}. Multiply \frac{x}{x-4} times \frac{x+4}{x+4}.
\frac{y\left(x-4\right)-x\left(x+4\right)}{\left(x-4\right)\left(x+4\right)}
Since \frac{y\left(x-4\right)}{\left(x-4\right)\left(x+4\right)} and \frac{x\left(x+4\right)}{\left(x-4\right)\left(x+4\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{yx-4y-x^{2}-4x}{\left(x-4\right)\left(x+4\right)}
Do the multiplications in y\left(x-4\right)-x\left(x+4\right).
\frac{yx-4y-x^{2}-4x}{x^{2}-16}
Expand \left(x-4\right)\left(x+4\right).