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2\left(x-6\right)-3\left(2x+8\right)=72
Multiply both sides of the equation by 6, the least common multiple of 3,2.
2x-12-3\left(2x+8\right)=72
Use the distributive property to multiply 2 by x-6.
2x-12-6x-24=72
Use the distributive property to multiply -3 by 2x+8.
-4x-12-24=72
Combine 2x and -6x to get -4x.
-4x-36=72
Subtract 24 from -12 to get -36.
-4x=72+36
Add 36 to both sides.
-4x=108
Add 72 and 36 to get 108.
x=\frac{108}{-4}
Divide both sides by -4.
x=-27
Divide 108 by -4 to get -27.