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\frac{\left(x-4\right)\left(-x+4\right)}{x\left(x+4\right)\left(-x+4\right)}-\frac{16x}{x\left(x+4\right)\left(-x+4\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x\left(x+4\right) and \left(4-x\right)\left(4+x\right) is x\left(x+4\right)\left(-x+4\right). Multiply \frac{x-4}{x\left(x+4\right)} times \frac{-x+4}{-x+4}. Multiply \frac{16}{\left(4-x\right)\left(4+x\right)} times \frac{x}{x}.
\frac{\left(x-4\right)\left(-x+4\right)-16x}{x\left(x+4\right)\left(-x+4\right)}
Since \frac{\left(x-4\right)\left(-x+4\right)}{x\left(x+4\right)\left(-x+4\right)} and \frac{16x}{x\left(x+4\right)\left(-x+4\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{-x^{2}+4x+4x-16-16x}{x\left(x+4\right)\left(-x+4\right)}
Do the multiplications in \left(x-4\right)\left(-x+4\right)-16x.
\frac{-x^{2}-8x-16}{x\left(x+4\right)\left(-x+4\right)}
Combine like terms in -x^{2}+4x+4x-16-16x.
\frac{\left(-x-4\right)\left(x+4\right)}{x\left(x+4\right)\left(-x+4\right)}
Factor the expressions that are not already factored in \frac{-x^{2}-8x-16}{x\left(x+4\right)\left(-x+4\right)}.
\frac{-\left(x+4\right)\left(x+4\right)}{x\left(x+4\right)\left(-x+4\right)}
Extract the negative sign in -4-x.
\frac{-\left(x+4\right)}{x\left(-x+4\right)}
Cancel out x+4 in both numerator and denominator.
\frac{-\left(x+4\right)}{-x^{2}+4x}
Expand x\left(-x+4\right).
\frac{-x-4}{-x^{2}+4x}
To find the opposite of x+4, find the opposite of each term.
\frac{\left(x-4\right)\left(-x+4\right)}{x\left(x+4\right)\left(-x+4\right)}-\frac{16x}{x\left(x+4\right)\left(-x+4\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x\left(x+4\right) and \left(4-x\right)\left(4+x\right) is x\left(x+4\right)\left(-x+4\right). Multiply \frac{x-4}{x\left(x+4\right)} times \frac{-x+4}{-x+4}. Multiply \frac{16}{\left(4-x\right)\left(4+x\right)} times \frac{x}{x}.
\frac{\left(x-4\right)\left(-x+4\right)-16x}{x\left(x+4\right)\left(-x+4\right)}
Since \frac{\left(x-4\right)\left(-x+4\right)}{x\left(x+4\right)\left(-x+4\right)} and \frac{16x}{x\left(x+4\right)\left(-x+4\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{-x^{2}+4x+4x-16-16x}{x\left(x+4\right)\left(-x+4\right)}
Do the multiplications in \left(x-4\right)\left(-x+4\right)-16x.
\frac{-x^{2}-8x-16}{x\left(x+4\right)\left(-x+4\right)}
Combine like terms in -x^{2}+4x+4x-16-16x.
\frac{\left(-x-4\right)\left(x+4\right)}{x\left(x+4\right)\left(-x+4\right)}
Factor the expressions that are not already factored in \frac{-x^{2}-8x-16}{x\left(x+4\right)\left(-x+4\right)}.
\frac{-\left(x+4\right)\left(x+4\right)}{x\left(x+4\right)\left(-x+4\right)}
Extract the negative sign in -4-x.
\frac{-\left(x+4\right)}{x\left(-x+4\right)}
Cancel out x+4 in both numerator and denominator.
\frac{-\left(x+4\right)}{-x^{2}+4x}
Expand x\left(-x+4\right).
\frac{-x-4}{-x^{2}+4x}
To find the opposite of x+4, find the opposite of each term.