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Differentiate w.r.t. x
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\frac{x}{\left(x-4\right)\left(x+4\right)}-\frac{4}{\left(x+1\right)\left(x+4\right)}
Factor x^{2}-16. Factor x^{2}+5x+4.
\frac{x\left(x+1\right)}{\left(x-4\right)\left(x+1\right)\left(x+4\right)}-\frac{4\left(x-4\right)}{\left(x-4\right)\left(x+1\right)\left(x+4\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of \left(x-4\right)\left(x+4\right) and \left(x+1\right)\left(x+4\right) is \left(x-4\right)\left(x+1\right)\left(x+4\right). Multiply \frac{x}{\left(x-4\right)\left(x+4\right)} times \frac{x+1}{x+1}. Multiply \frac{4}{\left(x+1\right)\left(x+4\right)} times \frac{x-4}{x-4}.
\frac{x\left(x+1\right)-4\left(x-4\right)}{\left(x-4\right)\left(x+1\right)\left(x+4\right)}
Since \frac{x\left(x+1\right)}{\left(x-4\right)\left(x+1\right)\left(x+4\right)} and \frac{4\left(x-4\right)}{\left(x-4\right)\left(x+1\right)\left(x+4\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{x^{2}+x-4x+16}{\left(x-4\right)\left(x+1\right)\left(x+4\right)}
Do the multiplications in x\left(x+1\right)-4\left(x-4\right).
\frac{x^{2}-3x+16}{\left(x-4\right)\left(x+1\right)\left(x+4\right)}
Combine like terms in x^{2}+x-4x+16.
\frac{x^{2}-3x+16}{x^{3}+x^{2}-16x-16}
Expand \left(x-4\right)\left(x+1\right)\left(x+4\right).