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Differentiate w.r.t. x
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\frac{x\left(x+2\right)}{\left(x+2\right)\left(x+6\right)}-\frac{3\left(x+6\right)}{\left(x+2\right)\left(x+6\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x+6 and x+2 is \left(x+2\right)\left(x+6\right). Multiply \frac{x}{x+6} times \frac{x+2}{x+2}. Multiply \frac{3}{x+2} times \frac{x+6}{x+6}.
\frac{x\left(x+2\right)-3\left(x+6\right)}{\left(x+2\right)\left(x+6\right)}
Since \frac{x\left(x+2\right)}{\left(x+2\right)\left(x+6\right)} and \frac{3\left(x+6\right)}{\left(x+2\right)\left(x+6\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{x^{2}+2x-3x-18}{\left(x+2\right)\left(x+6\right)}
Do the multiplications in x\left(x+2\right)-3\left(x+6\right).
\frac{x^{2}-x-18}{\left(x+2\right)\left(x+6\right)}
Combine like terms in x^{2}+2x-3x-18.
\frac{x^{2}-x-18}{x^{2}+8x+12}
Expand \left(x+2\right)\left(x+6\right).