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Differentiate w.r.t. x
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\frac{x\left(x-1\right)}{\left(x-1\right)\left(x+4\right)}-\frac{2\left(x+4\right)}{\left(x-1\right)\left(x+4\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x+4 and x-1 is \left(x-1\right)\left(x+4\right). Multiply \frac{x}{x+4} times \frac{x-1}{x-1}. Multiply \frac{2}{x-1} times \frac{x+4}{x+4}.
\frac{x\left(x-1\right)-2\left(x+4\right)}{\left(x-1\right)\left(x+4\right)}
Since \frac{x\left(x-1\right)}{\left(x-1\right)\left(x+4\right)} and \frac{2\left(x+4\right)}{\left(x-1\right)\left(x+4\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{x^{2}-x-2x-8}{\left(x-1\right)\left(x+4\right)}
Do the multiplications in x\left(x-1\right)-2\left(x+4\right).
\frac{x^{2}-3x-8}{\left(x-1\right)\left(x+4\right)}
Combine like terms in x^{2}-x-2x-8.
\frac{x^{2}-3x-8}{x^{2}+3x-4}
Expand \left(x-1\right)\left(x+4\right).