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Differentiate w.r.t. x
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\frac{x^{8}y^{12}}{x^{16}y^{12}}
Use the rules of exponents to simplify the expression.
x^{8-16}y^{12-12}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
x^{-8}y^{12-12}
Subtract 16 from 8.
x^{-8}y^{0}
Subtract 12 from 12.
\frac{1}{x^{8}}
For any number a except 0, a^{0}=1.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{x^{8}})
Cancel out x^{8}y^{12} in both numerator and denominator.
-\left(x^{8}\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}x}(x^{8})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(x^{8}\right)^{-2}\times 8x^{8-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-8x^{7}\left(x^{8}\right)^{-2}
Simplify.