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\frac{\left(x^{2}-9\right)\left(x-6\right)}{\left(x^{2}-4x-45\right)\left(-3-x\right)}
Multiply \frac{x^{2}-9}{x^{2}-4x-45} times \frac{x-6}{-3-x} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-6\right)\left(x-3\right)\left(x+3\right)}{\left(x-9\right)\left(-x-3\right)\left(x+5\right)}
Factor the expressions that are not already factored.
\frac{-\left(x-6\right)\left(x-3\right)\left(-x-3\right)}{\left(x-9\right)\left(-x-3\right)\left(x+5\right)}
Extract the negative sign in 3+x.
\frac{-\left(x-6\right)\left(x-3\right)}{\left(x-9\right)\left(x+5\right)}
Cancel out -x-3 in both numerator and denominator.
\frac{-x^{2}+9x-18}{x^{2}-4x-45}
Expand the expression.
\frac{\left(x^{2}-9\right)\left(x-6\right)}{\left(x^{2}-4x-45\right)\left(-3-x\right)}
Multiply \frac{x^{2}-9}{x^{2}-4x-45} times \frac{x-6}{-3-x} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-6\right)\left(x-3\right)\left(x+3\right)}{\left(x-9\right)\left(-x-3\right)\left(x+5\right)}
Factor the expressions that are not already factored.
\frac{-\left(x-6\right)\left(x-3\right)\left(-x-3\right)}{\left(x-9\right)\left(-x-3\right)\left(x+5\right)}
Extract the negative sign in 3+x.
\frac{-\left(x-6\right)\left(x-3\right)}{\left(x-9\right)\left(x+5\right)}
Cancel out -x-3 in both numerator and denominator.
\frac{-x^{2}+9x-18}{x^{2}-4x-45}
Expand the expression.