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\frac{\left(x-2\right)\left(x+2\right)}{\left(x-8\right)\left(x-2\right)}\times \frac{8-x}{x^{3}+8}
Factor the expressions that are not already factored in \frac{x^{2}-4}{x^{2}-10x+16}.
\frac{x+2}{x-8}\times \frac{8-x}{x^{3}+8}
Cancel out x-2 in both numerator and denominator.
\frac{\left(x+2\right)\left(8-x\right)}{\left(x-8\right)\left(x^{3}+8\right)}
Multiply \frac{x+2}{x-8} times \frac{8-x}{x^{3}+8} by multiplying numerator times numerator and denominator times denominator.
\frac{-\left(x-8\right)\left(x+2\right)}{\left(x-8\right)\left(x^{3}+8\right)}
Extract the negative sign in 8-x.
\frac{-\left(x+2\right)}{x^{3}+8}
Cancel out x-8 in both numerator and denominator.
\frac{-\left(x+2\right)}{\left(x+2\right)\left(x^{2}-2x+4\right)}
Factor the expressions that are not already factored.
\frac{-1}{x^{2}-2x+4}
Cancel out x+2 in both numerator and denominator.
\frac{\left(x-2\right)\left(x+2\right)}{\left(x-8\right)\left(x-2\right)}\times \frac{8-x}{x^{3}+8}
Factor the expressions that are not already factored in \frac{x^{2}-4}{x^{2}-10x+16}.
\frac{x+2}{x-8}\times \frac{8-x}{x^{3}+8}
Cancel out x-2 in both numerator and denominator.
\frac{\left(x+2\right)\left(8-x\right)}{\left(x-8\right)\left(x^{3}+8\right)}
Multiply \frac{x+2}{x-8} times \frac{8-x}{x^{3}+8} by multiplying numerator times numerator and denominator times denominator.
\frac{-\left(x-8\right)\left(x+2\right)}{\left(x-8\right)\left(x^{3}+8\right)}
Extract the negative sign in 8-x.
\frac{-\left(x+2\right)}{x^{3}+8}
Cancel out x-8 in both numerator and denominator.
\frac{-\left(x+2\right)}{\left(x+2\right)\left(x^{2}-2x+4\right)}
Factor the expressions that are not already factored.
\frac{-1}{x^{2}-2x+4}
Cancel out x+2 in both numerator and denominator.