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\frac{\left(x^{2}-2x-8\right)\left(x+3\right)}{\left(x^{2}+10x+21\right)\left(x-4\right)}
Multiply \frac{x^{2}-2x-8}{x^{2}+10x+21} times \frac{x+3}{x-4} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-4\right)\left(x+2\right)\left(x+3\right)}{\left(x-4\right)\left(x+3\right)\left(x+7\right)}
Factor the expressions that are not already factored.
\frac{x+2}{x+7}
Cancel out \left(x-4\right)\left(x+3\right) in both numerator and denominator.
\frac{\left(x^{2}-2x-8\right)\left(x+3\right)}{\left(x^{2}+10x+21\right)\left(x-4\right)}
Multiply \frac{x^{2}-2x-8}{x^{2}+10x+21} times \frac{x+3}{x-4} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-4\right)\left(x+2\right)\left(x+3\right)}{\left(x-4\right)\left(x+3\right)\left(x+7\right)}
Factor the expressions that are not already factored.
\frac{x+2}{x+7}
Cancel out \left(x-4\right)\left(x+3\right) in both numerator and denominator.