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\frac{\left(x-5\right)\left(x+8\right)}{\left(x+8\right)\left(x+9\right)}\times \frac{x^{2}-81}{x^{2}-25}
Factor the expressions that are not already factored in \frac{x^{2}+3x-40}{x^{2}+17x+72}.
\frac{x-5}{x+9}\times \frac{x^{2}-81}{x^{2}-25}
Cancel out x+8 in both numerator and denominator.
\frac{\left(x-5\right)\left(x^{2}-81\right)}{\left(x+9\right)\left(x^{2}-25\right)}
Multiply \frac{x-5}{x+9} times \frac{x^{2}-81}{x^{2}-25} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-9\right)\left(x-5\right)\left(x+9\right)}{\left(x-5\right)\left(x+5\right)\left(x+9\right)}
Factor the expressions that are not already factored.
\frac{x-9}{x+5}
Cancel out \left(x-5\right)\left(x+9\right) in both numerator and denominator.
\frac{\left(x-5\right)\left(x+8\right)}{\left(x+8\right)\left(x+9\right)}\times \frac{x^{2}-81}{x^{2}-25}
Factor the expressions that are not already factored in \frac{x^{2}+3x-40}{x^{2}+17x+72}.
\frac{x-5}{x+9}\times \frac{x^{2}-81}{x^{2}-25}
Cancel out x+8 in both numerator and denominator.
\frac{\left(x-5\right)\left(x^{2}-81\right)}{\left(x+9\right)\left(x^{2}-25\right)}
Multiply \frac{x-5}{x+9} times \frac{x^{2}-81}{x^{2}-25} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-9\right)\left(x-5\right)\left(x+9\right)}{\left(x-5\right)\left(x+5\right)\left(x+9\right)}
Factor the expressions that are not already factored.
\frac{x-9}{x+5}
Cancel out \left(x-5\right)\left(x+9\right) in both numerator and denominator.