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\frac{\left(x^{2}+2x+1\right)\left(x^{2}-16\right)}{\left(x^{2}+4x\right)\left(x^{2}-3x-4\right)}
Divide \frac{x^{2}+2x+1}{x^{2}+4x} by \frac{x^{2}-3x-4}{x^{2}-16} by multiplying \frac{x^{2}+2x+1}{x^{2}+4x} by the reciprocal of \frac{x^{2}-3x-4}{x^{2}-16}.
\frac{\left(x-4\right)\left(x+4\right)\left(x+1\right)^{2}}{x\left(x-4\right)\left(x+1\right)\left(x+4\right)}
Factor the expressions that are not already factored.
\frac{x+1}{x}
Cancel out \left(x-4\right)\left(x+1\right)\left(x+4\right) in both numerator and denominator.
\frac{\left(x^{2}+2x+1\right)\left(x^{2}-16\right)}{\left(x^{2}+4x\right)\left(x^{2}-3x-4\right)}
Divide \frac{x^{2}+2x+1}{x^{2}+4x} by \frac{x^{2}-3x-4}{x^{2}-16} by multiplying \frac{x^{2}+2x+1}{x^{2}+4x} by the reciprocal of \frac{x^{2}-3x-4}{x^{2}-16}.
\frac{\left(x-4\right)\left(x+4\right)\left(x+1\right)^{2}}{x\left(x-4\right)\left(x+1\right)\left(x+4\right)}
Factor the expressions that are not already factored.
\frac{x+1}{x}
Cancel out \left(x-4\right)\left(x+1\right)\left(x+4\right) in both numerator and denominator.