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\frac{\left(x^{2}+10x+25\right)\left(x^{2}-16\right)}{\left(x^{2}-8x+16\right)\left(x^{2}-25\right)}
Multiply \frac{x^{2}+10x+25}{x^{2}-8x+16} times \frac{x^{2}-16}{x^{2}-25} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-4\right)\left(x+4\right)\left(x+5\right)^{2}}{\left(x-5\right)\left(x+5\right)\left(x-4\right)^{2}}
Factor the expressions that are not already factored.
\frac{\left(x+4\right)\left(x+5\right)}{\left(x-5\right)\left(x-4\right)}
Cancel out \left(x-4\right)\left(x+5\right) in both numerator and denominator.
\frac{x^{2}+9x+20}{x^{2}-9x+20}
Expand the expression.
\frac{\left(x^{2}+10x+25\right)\left(x^{2}-16\right)}{\left(x^{2}-8x+16\right)\left(x^{2}-25\right)}
Multiply \frac{x^{2}+10x+25}{x^{2}-8x+16} times \frac{x^{2}-16}{x^{2}-25} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(x-4\right)\left(x+4\right)\left(x+5\right)^{2}}{\left(x-5\right)\left(x+5\right)\left(x-4\right)^{2}}
Factor the expressions that are not already factored.
\frac{\left(x+4\right)\left(x+5\right)}{\left(x-5\right)\left(x-4\right)}
Cancel out \left(x-4\right)\left(x+5\right) in both numerator and denominator.
\frac{x^{2}+9x+20}{x^{2}-9x+20}
Expand the expression.