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\frac{x+10}{\left(x-8\right)\left(x+10\right)}\times \frac{3}{-x-1}\times \frac{9x^{2}-63x-72}{x+1}
Factor the expressions that are not already factored in \frac{x+10}{x^{2}+2x-80}.
\frac{1}{x-8}\times \frac{3}{-x-1}\times \frac{9x^{2}-63x-72}{x+1}
Cancel out x+10 in both numerator and denominator.
\frac{1}{x-8}\times \frac{3}{-x-1}\times \frac{9\left(x-8\right)\left(x+1\right)}{x+1}
Factor the expressions that are not already factored in \frac{9x^{2}-63x-72}{x+1}.
\frac{1}{x-8}\times \frac{3}{-x-1}\times 9\left(x-8\right)
Cancel out x+1 in both numerator and denominator.
\frac{1}{x-8}\times \frac{3}{-x-1}\left(9x-72\right)
Expand the expression.
\frac{3}{\left(x-8\right)\left(-x-1\right)}\left(9x-72\right)
Multiply \frac{1}{x-8} times \frac{3}{-x-1} by multiplying numerator times numerator and denominator times denominator.
\frac{3\left(9x-72\right)}{\left(x-8\right)\left(-x-1\right)}
Express \frac{3}{\left(x-8\right)\left(-x-1\right)}\left(9x-72\right) as a single fraction.
\frac{3\times 9\left(x-8\right)}{\left(x-8\right)\left(-x-1\right)}
Factor the expressions that are not already factored.
\frac{3\times 9}{-x-1}
Cancel out x-8 in both numerator and denominator.
\frac{27}{-x-1}
Expand the expression.
\frac{x+10}{\left(x-8\right)\left(x+10\right)}\times \frac{3}{-x-1}\times \frac{9x^{2}-63x-72}{x+1}
Factor the expressions that are not already factored in \frac{x+10}{x^{2}+2x-80}.
\frac{1}{x-8}\times \frac{3}{-x-1}\times \frac{9x^{2}-63x-72}{x+1}
Cancel out x+10 in both numerator and denominator.
\frac{1}{x-8}\times \frac{3}{-x-1}\times \frac{9\left(x-8\right)\left(x+1\right)}{x+1}
Factor the expressions that are not already factored in \frac{9x^{2}-63x-72}{x+1}.
\frac{1}{x-8}\times \frac{3}{-x-1}\times 9\left(x-8\right)
Cancel out x+1 in both numerator and denominator.
\frac{1}{x-8}\times \frac{3}{-x-1}\left(9x-72\right)
Expand the expression.
\frac{3}{\left(x-8\right)\left(-x-1\right)}\left(9x-72\right)
Multiply \frac{1}{x-8} times \frac{3}{-x-1} by multiplying numerator times numerator and denominator times denominator.
\frac{3\left(9x-72\right)}{\left(x-8\right)\left(-x-1\right)}
Express \frac{3}{\left(x-8\right)\left(-x-1\right)}\left(9x-72\right) as a single fraction.
\frac{3\times 9\left(x-8\right)}{\left(x-8\right)\left(-x-1\right)}
Factor the expressions that are not already factored.
\frac{3\times 9}{-x-1}
Cancel out x-8 in both numerator and denominator.
\frac{27}{-x-1}
Expand the expression.