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Evaluate
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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{4\left(-x^{5}-x^{3}+x^{3}+x\right)}{x^{2}+1})
Cancel out 6 in both numerator and denominator.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{4\left(-x^{5}+x\right)}{x^{2}+1})
Combine -x^{3} and x^{3} to get 0.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{4x\left(x-1\right)\left(x+1\right)\left(-x^{2}-1\right)}{x^{2}+1})
Factor the expressions that are not already factored in \frac{4\left(-x^{5}+x\right)}{x^{2}+1}.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{-4x\left(x-1\right)\left(x+1\right)\left(x^{2}+1\right)}{x^{2}+1})
Extract the negative sign in -1-x^{2}.
\frac{\mathrm{d}}{\mathrm{d}x}(-4x\left(x-1\right)\left(x+1\right))
Cancel out x^{2}+1 in both numerator and denominator.
\frac{\mathrm{d}}{\mathrm{d}x}(-4x^{3}+4x)
Expand the expression.
3\left(-4\right)x^{3-1}+4x^{1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-12x^{3-1}+4x^{1-1}
Multiply 3 times -4.
-12x^{2}+4x^{1-1}
Subtract 1 from 3.
-12x^{2}+4x^{0}
Subtract 1 from 1.
-12x^{2}+4\times 1
For any term t except 0, t^{0}=1.
-12x^{2}+4
For any term t, t\times 1=t and 1t=t.