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Differentiate w.r.t. x
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\frac{5}{3}\times 15x^{\frac{5}{3}-1}-2\left(-6\right)x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
25x^{\frac{5}{3}-1}-2\left(-6\right)x^{-2-1}
Multiply \frac{5}{3} times 15.
25x^{\frac{2}{3}}-2\left(-6\right)x^{-2-1}
Subtract 1 from \frac{5}{3}.
25x^{\frac{2}{3}}+12x^{-2-1}
Multiply -2 times -6.
25x^{\frac{2}{3}}+12x^{-3}
Subtract 1 from -2.