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Differentiate w.r.t. a
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\frac{c^{8}}{c^{-2}a^{2}b^{4}}
Cancel out a^{2}b^{2} in both numerator and denominator.
\frac{c^{10}}{a^{2}b^{4}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{b^{2}c^{8}c^{2}}{b^{6}}a^{2-4})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{c^{10}}{b^{4}}a^{-2})
Do the arithmetic.
-2\times \frac{c^{10}}{b^{4}}a^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{2c^{10}}{b^{4}}\right)a^{-3}
Do the arithmetic.