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\frac{a^{2}-4a+16}{a^{2}-16}\times \frac{a^{3}-4a^{2}-16a+64}{-9a^{2}+36a-144}
Use the distributive property to multiply a+4 by a^{2}-8a+16 and combine like terms.
\frac{\left(a^{2}-4a+16\right)\left(a^{3}-4a^{2}-16a+64\right)}{\left(a^{2}-16\right)\left(-9a^{2}+36a-144\right)}
Multiply \frac{a^{2}-4a+16}{a^{2}-16} times \frac{a^{3}-4a^{2}-16a+64}{-9a^{2}+36a-144} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(a+4\right)\left(a-4\right)^{2}\left(a^{2}-4a+16\right)}{9\left(a-4\right)\left(a+4\right)\left(-a^{2}+4a-16\right)}
Factor the expressions that are not already factored.
\frac{-\left(a+4\right)\left(a-4\right)^{2}\left(-a^{2}+4a-16\right)}{9\left(a-4\right)\left(a+4\right)\left(-a^{2}+4a-16\right)}
Extract the negative sign in a^{2}-4a+16.
\frac{-\left(a-4\right)}{9}
Cancel out \left(a-4\right)\left(a+4\right)\left(-a^{2}+4a-16\right) in both numerator and denominator.
\frac{-a+4}{9}
Expand the expression.
\frac{a^{2}-4a+16}{a^{2}-16}\times \frac{a^{3}-4a^{2}-16a+64}{-9a^{2}+36a-144}
Use the distributive property to multiply a+4 by a^{2}-8a+16 and combine like terms.
\frac{\left(a^{2}-4a+16\right)\left(a^{3}-4a^{2}-16a+64\right)}{\left(a^{2}-16\right)\left(-9a^{2}+36a-144\right)}
Multiply \frac{a^{2}-4a+16}{a^{2}-16} times \frac{a^{3}-4a^{2}-16a+64}{-9a^{2}+36a-144} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(a+4\right)\left(a-4\right)^{2}\left(a^{2}-4a+16\right)}{9\left(a-4\right)\left(a+4\right)\left(-a^{2}+4a-16\right)}
Factor the expressions that are not already factored.
\frac{-\left(a+4\right)\left(a-4\right)^{2}\left(-a^{2}+4a-16\right)}{9\left(a-4\right)\left(a+4\right)\left(-a^{2}+4a-16\right)}
Extract the negative sign in a^{2}-4a+16.
\frac{-\left(a-4\right)}{9}
Cancel out \left(a-4\right)\left(a+4\right)\left(-a^{2}+4a-16\right) in both numerator and denominator.
\frac{-a+4}{9}
Expand the expression.