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\frac{\left(a^{2}+18a+80\right)\left(a^{2}+6a-27\right)}{\left(a^{2}+4a-21\right)\left(a^{2}+20a+100\right)}
Multiply \frac{a^{2}+18a+80}{a^{2}+4a-21} times \frac{a^{2}+6a-27}{a^{2}+20a+100} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(a-3\right)\left(a+8\right)\left(a+9\right)\left(a+10\right)}{\left(a-3\right)\left(a+7\right)\left(a+10\right)^{2}}
Factor the expressions that are not already factored.
\frac{\left(a+8\right)\left(a+9\right)}{\left(a+7\right)\left(a+10\right)}
Cancel out \left(a-3\right)\left(a+10\right) in both numerator and denominator.
\frac{a^{2}+17a+72}{a^{2}+17a+70}
Expand the expression.
\frac{\left(a^{2}+18a+80\right)\left(a^{2}+6a-27\right)}{\left(a^{2}+4a-21\right)\left(a^{2}+20a+100\right)}
Multiply \frac{a^{2}+18a+80}{a^{2}+4a-21} times \frac{a^{2}+6a-27}{a^{2}+20a+100} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(a-3\right)\left(a+8\right)\left(a+9\right)\left(a+10\right)}{\left(a-3\right)\left(a+7\right)\left(a+10\right)^{2}}
Factor the expressions that are not already factored.
\frac{\left(a+8\right)\left(a+9\right)}{\left(a+7\right)\left(a+10\right)}
Cancel out \left(a-3\right)\left(a+10\right) in both numerator and denominator.
\frac{a^{2}+17a+72}{a^{2}+17a+70}
Expand the expression.