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Differentiate w.r.t. a
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\frac{a^{\frac{2}{3}}}{a^{\frac{8}{3}}}
Use the rules of exponents to simplify the expression.
a^{\frac{2}{3}-\frac{8}{3}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
a^{-2}
Subtract \frac{8}{3} from \frac{2}{3} by finding a common denominator and subtracting the numerators. Then reduce the fraction to lowest terms if possible.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{1}a^{\frac{2}{3}-\frac{8}{3}})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{-2})
Do the arithmetic.
-2a^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-2a^{-3}
Do the arithmetic.