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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{b^{2}c^{7}c^{6}b^{8}}a^{-5-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{b^{10}c^{13}}a^{-8})
Do the arithmetic.
-8\times \frac{1}{b^{10}c^{13}}a^{-8-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{8}{b^{10}c^{13}}\right)a^{-9}
Do the arithmetic.
\frac{1}{a^{8}b^{10}c^{13}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.