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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{1}a^{-1-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{-3})
Do the arithmetic.
-3a^{-3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-3a^{-4}
Do the arithmetic.
\frac{1}{a^{3}}
Rewrite a^{2} as a^{-1}a^{3}. Cancel out a^{-1} in both numerator and denominator.