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Differentiate w.r.t. x
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\frac{81x^{18}y^{0}z^{-4}z^{-4}}{81x^{12}y^{-12}z^{-4}}
To multiply powers of the same base, add their exponents. Add 14 and 4 to get 18.
\frac{81x^{18}y^{0}z^{-8}}{81x^{12}y^{-12}z^{-4}}
To multiply powers of the same base, add their exponents. Add -4 and -4 to get -8.
\frac{z^{-8}y^{0}x^{6}}{y^{-12}z^{-4}}
Cancel out 81x^{12} in both numerator and denominator.
\frac{z^{-8}x^{6}y^{12}}{z^{-4}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{x^{6}y^{12}}{z^{4}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{81y^{0}x^{4}}{z^{4}z^{4}\times \frac{81}{z^{4}y^{12}}}x^{14-12})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{x^{4}y^{12}}{z^{4}}x^{2})
Do the arithmetic.
2\times \frac{x^{4}y^{12}}{z^{4}}x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{2x^{4}y^{12}}{z^{4}}x^{1}
Do the arithmetic.
\frac{2x^{4}y^{12}}{z^{4}}x
For any term t, t^{1}=t.