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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{8y^{4x^{2}}}{4y^{4}}x^{-3-\left(-1\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(2y^{4x^{2}-4}x^{-2})
Do the arithmetic.
-2\times 2y^{4x^{2}-4}x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-4y^{4x^{2}-4}\right)x^{-3}
Do the arithmetic.