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Differentiate w.r.t. u
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\frac{8^{1}t^{10}u^{3}}{2^{1}t^{2}u^{9}}
Use the rules of exponents to simplify the expression.
\frac{8^{1}}{2^{1}}t^{10-2}u^{3-9}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{8^{1}}{2^{1}}t^{8}u^{3-9}
Subtract 2 from 10.
\frac{8^{1}}{2^{1}}t^{8}u^{-6}
Subtract 9 from 3.
4t^{8}\times \frac{1}{u^{6}}
Divide 8 by 2.