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Differentiate w.r.t. a
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\frac{4c^{-6}a^{-2}b^{7}}{b^{-2}a^{8}c^{8}}
Cancel out 2 in both numerator and denominator.
\frac{4c^{-6}a^{-2}b^{9}}{a^{8}c^{8}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{4b^{9}}{a^{10}c^{14}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{8b^{7}}{c^{6}\times \frac{2c^{8}}{b^{2}}}a^{-2-8})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{4b^{9}}{c^{14}}a^{-10})
Do the arithmetic.
-10\times \frac{4b^{9}}{c^{14}}a^{-10-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{40b^{9}}{c^{14}}\right)a^{-11}
Do the arithmetic.