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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{6y^{\frac{4}{3}}}{\sqrt[5]{z}\times 5y^{1}z^{2}}x^{\frac{2}{3}-4})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{6\sqrt[3]{y}}{5z^{\frac{11}{5}}}x^{-\frac{10}{3}})
Do the arithmetic.
-\frac{10}{3}\times \frac{6\sqrt[3]{y}}{5z^{\frac{11}{5}}}x^{-\frac{10}{3}-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{4\sqrt[3]{y}}{z^{\frac{11}{5}}}\right)x^{-\frac{13}{3}}
Do the arithmetic.