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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{5z^{2}y^{4}}{20yz^{6}}x^{1-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{y^{3}}{4z^{4}}x^{-2})
Do the arithmetic.
-2\times \frac{y^{3}}{4z^{4}}x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{y^{3}}{2z^{4}}\right)x^{-3}
Do the arithmetic.
\frac{y^{3}}{4x^{2}z^{4}}
Cancel out 5xyz^{2} in both numerator and denominator.