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Differentiate w.r.t. x
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\frac{5x\left(x-4\right)}{\left(x-4\right)\left(2x+3\right)}-\frac{9\left(2x+3\right)}{\left(x-4\right)\left(2x+3\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of 2x+3 and x-4 is \left(x-4\right)\left(2x+3\right). Multiply \frac{5x}{2x+3} times \frac{x-4}{x-4}. Multiply \frac{9}{x-4} times \frac{2x+3}{2x+3}.
\frac{5x\left(x-4\right)-9\left(2x+3\right)}{\left(x-4\right)\left(2x+3\right)}
Since \frac{5x\left(x-4\right)}{\left(x-4\right)\left(2x+3\right)} and \frac{9\left(2x+3\right)}{\left(x-4\right)\left(2x+3\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{5x^{2}-20x-18x-27}{\left(x-4\right)\left(2x+3\right)}
Do the multiplications in 5x\left(x-4\right)-9\left(2x+3\right).
\frac{5x^{2}-38x-27}{\left(x-4\right)\left(2x+3\right)}
Combine like terms in 5x^{2}-20x-18x-27.
\frac{5x^{2}-38x-27}{2x^{2}-5x-12}
Expand \left(x-4\right)\left(2x+3\right).