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Differentiate w.r.t. x
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\frac{5}{\left(x-4\right)\left(x-2\right)}-\frac{2}{\left(x-4\right)^{2}}
Factor x^{2}-6x+8. Factor x^{2}-8x+16.
\frac{5\left(x-4\right)}{\left(x-2\right)\left(x-4\right)^{2}}-\frac{2\left(x-2\right)}{\left(x-2\right)\left(x-4\right)^{2}}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of \left(x-4\right)\left(x-2\right) and \left(x-4\right)^{2} is \left(x-2\right)\left(x-4\right)^{2}. Multiply \frac{5}{\left(x-4\right)\left(x-2\right)} times \frac{x-4}{x-4}. Multiply \frac{2}{\left(x-4\right)^{2}} times \frac{x-2}{x-2}.
\frac{5\left(x-4\right)-2\left(x-2\right)}{\left(x-2\right)\left(x-4\right)^{2}}
Since \frac{5\left(x-4\right)}{\left(x-2\right)\left(x-4\right)^{2}} and \frac{2\left(x-2\right)}{\left(x-2\right)\left(x-4\right)^{2}} have the same denominator, subtract them by subtracting their numerators.
\frac{5x-20-2x+4}{\left(x-2\right)\left(x-4\right)^{2}}
Do the multiplications in 5\left(x-4\right)-2\left(x-2\right).
\frac{3x-16}{\left(x-2\right)\left(x-4\right)^{2}}
Combine like terms in 5x-20-2x+4.
\frac{3x-16}{x^{3}-10x^{2}+32x-32}
Expand \left(x-2\right)\left(x-4\right)^{2}.