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\frac{5^{-4}\times 2^{-2}}{2^{2}\times 5^{-5}}
To multiply powers of the same base, add their exponents. Add -3 and 5 to get 2.
\frac{2^{-2}\times 5^{1}}{2^{2}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{5^{1}}{2^{4}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{5}{2^{4}}
Calculate 5 to the power of 1 and get 5.
\frac{5}{16}
Calculate 2 to the power of 4 and get 16.