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\frac{49}{4}-\frac{65}{16}a^{2}+a^{4}+\frac{\left(-4a+1\right)\left(a-2\right)\left(4a+1\right)\left(a+2\right)}{16}
Combine -\frac{a^{2}}{16} and -4a^{2} to get -\frac{65}{16}a^{2}.
\frac{49\times 4}{16}-\frac{65}{16}a^{2}+a^{4}+\frac{\left(-4a+1\right)\left(a-2\right)\left(4a+1\right)\left(a+2\right)}{16}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of 4 and 16 is 16. Multiply \frac{49}{4} times \frac{4}{4}.
\frac{49\times 4+\left(-4a+1\right)\left(a-2\right)\left(4a+1\right)\left(a+2\right)}{16}-\frac{65}{16}a^{2}+a^{4}
Since \frac{49\times 4}{16} and \frac{\left(-4a+1\right)\left(a-2\right)\left(4a+1\right)\left(a+2\right)}{16} have the same denominator, add them by adding their numerators.
\frac{196-16a^{4}-4a^{3}+64a^{2}+16a+4a^{3}+a^{2}-16a-4}{16}-\frac{65}{16}a^{2}+a^{4}
Do the multiplications in 49\times 4+\left(-4a+1\right)\left(a-2\right)\left(4a+1\right)\left(a+2\right).
\frac{192-16a^{4}+65a^{2}}{16}-\frac{65}{16}a^{2}+a^{4}
Combine like terms in 196-16a^{4}-4a^{3}+64a^{2}+16a+4a^{3}+a^{2}-16a-4.
12+\frac{65}{16}a^{2}-a^{4}-\frac{65}{16}a^{2}+a^{4}
Divide each term of 192-16a^{4}+65a^{2} by 16 to get 12+\frac{65}{16}a^{2}-a^{4}.
12-a^{4}+a^{4}
Combine \frac{65}{16}a^{2} and -\frac{65}{16}a^{2} to get 0.
12
Combine -a^{4} and a^{4} to get 0.
\frac{196-a^{2}+16a^{4}-64a^{2}+\left(-4a+1\right)\left(a-2\right)\left(4a+1\right)\left(a+2\right)}{16}
Factor out \frac{1}{16}.
12
Simplify.