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\frac{45a^{2}}{14x^{2}}-\frac{49x^{4}}{18a^{4}}
Cancel out a in both numerator and denominator.
\frac{45a^{2}\times 9a^{4}}{126x^{2}a^{4}}-\frac{49x^{4}\times 7x^{2}}{126x^{2}a^{4}}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of 14x^{2} and 18a^{4} is 126x^{2}a^{4}. Multiply \frac{45a^{2}}{14x^{2}} times \frac{9a^{4}}{9a^{4}}. Multiply \frac{49x^{4}}{18a^{4}} times \frac{7x^{2}}{7x^{2}}.
\frac{45a^{2}\times 9a^{4}-49x^{4}\times 7x^{2}}{126x^{2}a^{4}}
Since \frac{45a^{2}\times 9a^{4}}{126x^{2}a^{4}} and \frac{49x^{4}\times 7x^{2}}{126x^{2}a^{4}} have the same denominator, subtract them by subtracting their numerators.
\frac{405a^{6}-343x^{6}}{126x^{2}a^{4}}
Do the multiplications in 45a^{2}\times 9a^{4}-49x^{4}\times 7x^{2}.