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Differentiate w.r.t. x
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\frac{4x\left(x-2\right)}{\left(x-4\right)\left(x-2\right)}-\frac{2\left(x-4\right)}{\left(x-4\right)\left(x-2\right)}-1
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x-4 and x-2 is \left(x-4\right)\left(x-2\right). Multiply \frac{4x}{x-4} times \frac{x-2}{x-2}. Multiply \frac{2}{x-2} times \frac{x-4}{x-4}.
\frac{4x\left(x-2\right)-2\left(x-4\right)}{\left(x-4\right)\left(x-2\right)}-1
Since \frac{4x\left(x-2\right)}{\left(x-4\right)\left(x-2\right)} and \frac{2\left(x-4\right)}{\left(x-4\right)\left(x-2\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{4x^{2}-8x-2x+8}{\left(x-4\right)\left(x-2\right)}-1
Do the multiplications in 4x\left(x-2\right)-2\left(x-4\right).
\frac{4x^{2}-10x+8}{\left(x-4\right)\left(x-2\right)}-1
Combine like terms in 4x^{2}-8x-2x+8.
\frac{4x^{2}-10x+8}{\left(x-4\right)\left(x-2\right)}-\frac{\left(x-4\right)\left(x-2\right)}{\left(x-4\right)\left(x-2\right)}
To add or subtract expressions, expand them to make their denominators the same. Multiply 1 times \frac{\left(x-4\right)\left(x-2\right)}{\left(x-4\right)\left(x-2\right)}.
\frac{4x^{2}-10x+8-\left(x-4\right)\left(x-2\right)}{\left(x-4\right)\left(x-2\right)}
Since \frac{4x^{2}-10x+8}{\left(x-4\right)\left(x-2\right)} and \frac{\left(x-4\right)\left(x-2\right)}{\left(x-4\right)\left(x-2\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{4x^{2}-10x+8-x^{2}+2x+4x-8}{\left(x-4\right)\left(x-2\right)}
Do the multiplications in 4x^{2}-10x+8-\left(x-4\right)\left(x-2\right).
\frac{3x^{2}-4x}{\left(x-4\right)\left(x-2\right)}
Combine like terms in 4x^{2}-10x+8-x^{2}+2x+4x-8.
\frac{3x^{2}-4x}{x^{2}-6x+8}
Expand \left(x-4\right)\left(x-2\right).