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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{4y^{3}z^{6}}{yz^{5}}x^{3-1})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(4zy^{2}x^{2})
Do the arithmetic.
2\times 4zy^{2}x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
8zy^{2}x^{1}
Do the arithmetic.
8zy^{2}x
For any term t, t^{1}=t.
4zx^{2}y^{2}
Cancel out xyz^{5} in both numerator and denominator.